Flow cytometry-based diagnosis of primary immunodeficiency diseases

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Flow cytometry-based diagnosis of primary immunodeficiency diseases.

Primary immunodeficiencies (PIDs) are a heterogeneous group of inherited diseases of the immune system. The definite diagnosis of PID is ascertained by genetic analysis; however, this takes time and is costly. Flow cytometry provides a rapid and highly sensitive tool for diagnosis of PIDs. Flow cytometry can evaluate specific cell populations and subpopulations, cell surface, intracellular and ...

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Role of flow cytometry in the diagnosis and monitoring of primary immunodeficiency disease.

This presentation is organized according to the recent classification of primary immunodeficiencies published by the International Union of Immunological Societies Primary Immunodeficiency meeting. The diseases have been classified into eight groups. After each list, individual diseases that are amenable to assessment by flow cytometry are reviewed with a brief clinical description and a discus...

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Because of recent advances in instrumentation, immunological reagents, and methods for measuring a variety of cell constituents and functions, there has been increasing interest in clinical applications of flow cytometry. Several commercially available flow cytometers and a growing list of monoclonal antibodies make it feasible for clinical laboratories to apply this technology for phenotyping ...

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ژورنال

عنوان ژورنال: Allergology International

سال: 2018

ISSN: 1323-8930

DOI: 10.1016/j.alit.2017.06.003